Article

The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells

2026-03-05

Abstract excerpt

Maintenance of the gas exchange surface throughout life and regeneration of the lung after injury requires tight regulation of epithelial cell fate and function. Alveolar epithelial type 2 (AT2) cells serve as the progenitors of the distal epithelium, differentiating into alveolar epithelial type 1 (AT1) cells or proliferating to maintain the quorum of AT2 cells. Here we describe the role of the chromatin regulato...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d51103a-b717-550f-aba9-3f3d45ea287f
DOI: 10.64898/2026.03.03.708777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cellsDOI 10.64898/2026.03.03.708777Read

An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injurySemantic proximity Read

A molecular circuit regulates fate plasticity in emerging and adult AT2 cellsSemantic proximity Read

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In VitroSemantic proximity Read

AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repairSemantic proximity Read

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identitySemantic proximity Read

Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human LungsSemantic proximity Read

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF)Semantic proximity Read

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identitySemantic proximity Read

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1Semantic proximity Read

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungsSemantic proximity Read

<i>Let-7</i> restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosisSemantic proximity Read

Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.Semantic proximity Read