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Article

β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation.

Journal of radiation research - 1 Jan 2021

Liu Xiaozhuan, Zhang Tingting, Zhou Jianwei, Xiao Ziting, Li Yanjun, Zhang Yuwei, Yue Haodi, Li Zhitao, Tian Jian

Abstract excerpt

The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study was to track AEC II phenotypes at different phases of injury following thoracic irradiation and examine the expression...

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Source

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Identifiers

PMID: 33302295
DOI: 10.1093/jrr/rraa119
PMCID: PMC7779353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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