Article
p53 governs an AT1 differentiation programme in lung cancer suppression.
Nature - 1 Jul 2023
Kaiser Alyssa M, Gatto Alberto, Hanson Kathryn J, Zhao Richard L, Raj Nitin, Ozawa Michael G, Seoane José A, Bieging-Rolett Kathryn T, Wang Mengxiong, Li Irene, Trope Winston L, Liou Douglas Z, Shrager Joseph B, Plevritis Sylvia K, Newman Aaron M, Van Rechem Capucine, Attardi Laura D
Abstract excerpt
Lung cancer is the leading cause of cancer deaths worldwide1. Mutations in the tumour suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis1-4, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, specifically by promoting alveolar type 1 (AT1) differentiation. Using mice that express oncogenic Kras...
Topics
- Animals
- Mice
- Alveolar Epithelial Cells
- Cell Differentiation
- Lung
- Lung Neoplasms
- Mice, Knockout
- Tumor Suppressor Protein p53
- Alleles
- Gene Expression Profiling