Article

AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repair

2025-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Facultative stem cells including lung alveolar type 2 (AT2) cells must toggle between unipotent specialization at baseline and multipotent plasticity during injury-repair. The underlying molecular switches and epigenetic changes remain unclear yet dictate regenerative versus pathological outcomes. Using multiomics and mouse genetics, we show that AP-1 members FOS, FOSB, and JUNB promote an injur...

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Literature Corpus work: ea1b887b-6073-5669-8dfa-536666fddde7
DOI: 10.1101/2025.10.25.684549

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