Article

Delayed DNA replication in haploid human embryonic stem cells

2021-05-12

Abstract excerpt

Haploid human embryonic stem cells (ESCs) provide a powerful genetic system but diploidize at high rates. We hypothesized that diploidization results from aberrant DNA replication. To test this, we profiled DNA replication timing in isogenic haploid and diploid ESCs. The greatest difference was the earlier replication of the X chromosome in haploids, consistent with the lack of X chromosome inactivation. Surprisin...

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Literature Corpus work: bb0c07a9-18ce-51f6-8d6d-c8219abd1c6f
DOI: 10.1101/2021.05.11.443666

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