Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryonic genome instability upon DNA replication timing program emergence

28 Aug 2024

Abstract excerpt

Faithful DNA replication is essential for genome integrity1–4. Under-replicated DNA leads to defects in chromosome segregation, which are common during embryogenesis5–8. However, the regulation of DNA replication remains poorly understood in early mammalian embryos. Here we constructed a single-cell genome-wide DNA replication atlas of pre-implantation mouse embryos and identified an abrupt replication program...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39198647
DOI: 10.1038/s41586-024-07841-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryonic genome instability upon DNA replication timing program emergencePMID 39198647Read ↗

Sex-specific DNA-replication in the early mammalian embryoSemantic proximity Read ↗

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read ↗

Delayed DNA replication in haploid human embryonic stem cellsSemantic proximity Read ↗

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragilitySemantic proximity Read ↗

Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies <i>MCM10</i> as a novel regulator of the replication programSemantic proximity Read ↗

Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem CellsSemantic proximity Read ↗

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryosSemantic proximity Read ↗

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read ↗

Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determinationSemantic proximity Read ↗

Novel Single-Cell Multiomics Approach to Analyze Replication Timing and Gene Expression in Mouse Preimplantation EmbryosSemantic proximity Read ↗

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.Semantic proximity Read ↗

Replication timing and transcriptional control: beyond cause and effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.