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Decoding Clonal Hematopoiesis: Emerging Themes and Novel Mechanistic Insights

24 Jul 2024

Abstract excerpt

Clonal hematopoiesis (CH), the relative expansion of mutant clones, is derived from hematopoietic stem cells (HSCs) with acquired somatic or cytogenetic alterations that improve cellular fitness. Individuals with CH have a higher risk for hematological and non-hematological diseases, such as cardiovascular disease, and have an overall higher mortality rate. Originally thought to be restricted to a small fraction...

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PMID: 39123361
DOI: 10.3390/cancers16152634

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