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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

2024-11-20

Abstract excerpt

<h4>Background</h4> Both the expression and activities of LINE-1 (L1) retrotransposons are known to occur in numerous cell-types and are implicated in pathobiological contexts such as aging-related inflammation, autoimmunity, and in cancers. L1s encode two proteins that are translated from bicistronic transcripts. The translation product of ORF1 (ORF1p) has been robustly detected by immunoassays and shotgun mass...

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Literature Corpus work
034af5c2-5123-5e52-8943-72c2a12a3209
DOI
10.1101/2024.11.20.624490
Open publication

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Targeted detection of endogenous LINE-1 proteins and ORF2p interactionsDOI 10.1101/2024.11.20.624490
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