Article

LINE-1 ORF1p is a shared and immunogenic antigen in cancer

2025-06-17

Abstract excerpt

<h4>Background</h4> Recent clinical trials are beginning to show the potential for therapeutic cancer vaccines directed against tumor associated antigens. However, there is a limited set of well-defined antigens that are shared across tumors. Noncanonical coding elements in the genome that are usually silenced in normal cells potentially represent a rich source of “dark” antigens when expressed and presented to t...

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Literature Corpus work: bd012e57-3164-573a-943e-20cc1546628b
DOI: 10.1101/2025.06.11.659092

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