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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

6 Feb 2025

Abstract excerpt

BACKGROUND: Both the expression and activities of LINE-1 (L1) retrotransposons are known to occur in numerous cell-types and are implicated in pathobiological contexts such as aging-related inflammation, autoimmunity, and in cancers. L1s encode two proteins that are translated from bicistronic transcripts. The translation product of ORF1 (ORF1p) has been robustly detected by immunoassays and shotgun mass...

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PMID: 39915890
DOI: 10.1186/s13100-024-00339-4

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