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Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

12 Sept 2023

Abstract excerpt

Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring treatment response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity for these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element protein overexpressed in carcinomas and high-risk...

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PMID: 37698949
DOI: 10.1158/2159-8290.cd-23-0313

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