Article

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer’s disease

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> cAMP-dependent Protein Kinase A (PKA) is a master regulator of cell signaling involved in energy metabolism, synaptic plasticity, and stress response. Dysregulated PKA signaling is implicated in diseases including neurodegeneration and cancer. PKA catalytic activity is regulated by two nonredundant regulatory subunits, Type I (RIα/RIβ) and Type II (RIIα/RIIβ), whose divergent functions are not f...

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Literature Corpus work: c1299766-39c3-5309-b524-19b6ca881caa
DOI: 10.64898/2026.06.26.734839

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