Article
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.
The Biochemical journal - 11 Jun 2021
Taylor Susan S, Wallbott Maximilian, Machal Erik M F, Søberg Kristoffer, Ahmed Faihaa, Bruystens Jessica, Vu Lily, Baker Blaine, Wu Jian, Raimondi Francesco, Ongeri Elimelda M, Herberg Friedrich W, Skålhegg Bjørn S
Abstract excerpt
3',5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in eukaryotic cells. The PKA catalytic subunits are encoded by the two major genes PRKACA and PRKACB, respectively. The PRKACA gene encodes two known splice variants, the ubiquitously expressed Cα1 and...
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