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Article

Protein kinase A is a target for aging and the aging heart.

Aging - 1 Apr 2010

Enns Linda C, Pettan-Brewer Christina, Ladiges Warren

Abstract excerpt

PKA is an important mediator of signal transduction downstream of G-protein-coupled receptors and plays a key role in the regulation of metabolism and triglyceride storage. It is a ubiquitous cellular kinase that phosphorylates serine and threonine residues in response to cAMP. PKA consists of tw...

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Identifiers

PMID: 20448293
DOI: 10.18632/aging.100138
PMCID: PMC2881512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20448293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase A is a target for aging and the aging heart.PMID 20448293Read ↗

Disruption of protein kinase A in mice enhances healthy aging.Semantic proximity Read ↗

Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.Semantic proximity Read ↗

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer’s diseaseSemantic proximity Read ↗

Cell-type specific expression of a dominant negative PKA mutation in mice.Semantic proximity Read ↗

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.Semantic proximity Read ↗

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.Semantic proximity Read ↗

Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue.Semantic proximity Read ↗

Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.Semantic proximity Read ↗

Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.Semantic proximity Read ↗

Protein Kinase A in neurological disordersSemantic proximity Read ↗

Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice.Semantic proximity Read ↗

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control.Semantic proximity Read ↗

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