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Article

Protein kinase A is a target for aging and the aging heart.

Aging - 1 Apr 2010

Enns Linda C, Pettan-Brewer Christina, Ladiges Warren

Abstract excerpt

PKA is an important mediator of signal transduction downstream of G-protein-coupled receptors and plays a key role in the regulation of metabolism and triglyceride storage. It is a ubiquitous cellular kinase that phosphorylates serine and threonine residues in response to cAMP. PKA consists of two regulatory subunits, RI and RII, that are activated by cAMP to release two catalytic subunits, Calpha and Cbeta. We...

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Identifiers

PMID: 20448293
DOI: 10.18632/aging.100138
PMCID: PMC2881512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein kinase A is a target for aging and the aging heart.PMID 20448293Read ↗

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Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.Semantic proximity Read ↗

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer’s diseaseSemantic proximity Read ↗

Cell-type specific expression of a dominant negative PKA mutation in mice.Semantic proximity Read ↗

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.Semantic proximity Read ↗

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.Semantic proximity Read ↗

Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue.Semantic proximity Read ↗

Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.Semantic proximity Read ↗

Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.Semantic proximity Read ↗

Protein Kinase A in neurological disordersSemantic proximity Read ↗

Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice.Semantic proximity Read ↗

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control.Semantic proximity Read ↗

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