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Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

2025-03-13

Abstract excerpt

<title>Abstract</title> <p>Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI complex through selective autophagy. However, the neuronal functions of AKAP11 and the impact o...

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Literature Corpus work
525d4874-67c8-5a65-9d7b-ded2cd465798
DOI
10.21203/rs.3.rs-6043477/v1
Open publication

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Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmissionDOI 10.21203/rs.3.rs-6043477/v1
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