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Bipolar and schizophrenia risk gene <i>AKAP11</i> encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

2024-12-31

Abstract excerpt

Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI complex through selective autophagy. However, the neuronal functions of AKAP11 and the impact of its loss-of-function rema...

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Literature Corpus work
447c0bb8-52f4-5e30-9347-d12f324720aa
DOI
10.1101/2024.12.30.630813
Open publication

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Bipolar and schizophrenia risk gene <i>AKAP11</i> encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmissionDOI 10.1101/2024.12.30.630813
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