Article

Age-related decline of PKA-RIIβ level in SNc dopaminergic neurons underlies PD pathogenesis

2024-09-15

Abstract excerpt

The cyclic-AMP dependent protein kinase A (Protein kinase A, PKA) regulates dopaminergic function in the substantia nigra pars compacta (SNc). However, whether PKA is involved in the pathogenesis of Parkinson’s disease (PD) is unknown. Here, by collecting and analyzing the current worldwide SNc transcriptomic datasets of PD patients, we found a decline of PKA-RIIβ subunit level in the SNc of PD patients. The decre...

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Literature Corpus work: ddc37198-293a-59e3-9d8b-4906652c8c8f
DOI: 10.1101/2024.09.13.612981

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Age-related decline of PKA-RIIβ level in SNc dopaminergic neurons underlies PD pathogenesisDOI 10.1101/2024.09.13.612981Read

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