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Article

Aberrant phase separation of two PKA RIβ neurological disorder mutants leads to mechanistically distinct signaling deficits.

Cell reports - 24 Jun 2025

Pool Emily H, Glebov-McCloud Alexander, Lee Ha Neul, Hardy Julia C, Pane Valeria, Herberg Friedrich W, Taylor Susan S, Mehta Sohum, Strack Stefan, Zhang Jin

Abstract excerpt

Spatiotemporal regulation of key-node signaling molecules, such as 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), is critical for normal cell physiology and susceptible to dysregulation in disease. Liquid-liquid phase separation (LLPS) is broadly recognized as a fundamental component of signal regulation, yet the connections between physiological and disease-linked biomolecular...

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Identifiers

PMID: 40512625
DOI: 10.1016/j.celrep.2025.115797
PMCID: PMC12369641

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