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Article

Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization.

PLoS biology - 1 Jul 2025

Lee Ha Neul, Hardy Julia C, Pool Emily H, Zhang Jin-Fan, Kim Su Hyun, Buhl William F, Bruystens Jessica G H, Mehta Sohum, Taylor Susan S, Zhang Jin

Abstract excerpt

Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid-liquid phase separation (LLPS) to facilitate spatial compartmentalization of cAMP. However, how RIα LLPS regulates cellular function is largely unknown. Here, we...

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Identifiers

PMID: 40705714
DOI: 10.1371/journal.pbio.3003262
PMCID: PMC12289088

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