Article

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressed

2024-07-01

Abstract excerpt

Protein kinase A (PKA) is a crucial signaling enzyme in neurons, with its dysregulation being implicated in neurodegenerative diseases. Assembly of the PKA holoenzyme, comprising a dimer of heterodimers of regulatory (R) and catalytic (C) subunits, ensures allosteric regulation and functional specificity. Recently, we defined the RIβ-L50R variant as a causative mutation that triggers protein aggregation in a rare...

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Literature Corpus work: 6e4936e1-972b-5018-8436-1bb69304d85c
DOI: 10.1101/2024.06.30.601371

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Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressedDOI 10.1101/2024.06.30.601371Read

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