Article

The extracellular ATP/P2X7R signaling axis drives early neuroinflammation and neuronal hyperexcitability in an Alzheimer’s disease mouse model

2025-11-14

Abstract excerpt

Neuroinflammation and synaptic dysfunction are emerging as early and potentially causative events in Alzheimer’s disease (AD), yet their molecular triggers remain elusive. Here, we identify extracellular ATP (eATP), a major damage-associated molecular pattern, and its purinergic receptor P2X7 (P2X7R) as pivotal drivers of early pathology in AD mice. In vivo bioluminescence imaging revealed a significant cortical...

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Literature Corpus work: c0d5b6c9-abda-5aba-ba36-4ac13bf3b4c4
DOI: 10.1101/2025.11.14.688405

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