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Article

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

3 May 2018

Abstract excerpt

Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer’s disease (AD). We have previously shown that astrocyte hyperactivity is mediated by signaling through the P2Y1 purinoreceptor (P2Y1R) pathway. Using the APPPS1 mouse model of AD, we here find that chronic intracerebroventricular infusion of P2Y1R inhibitors normalizes astroglial and neuronal network...

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Share to Adenosine and Purinergic Signaling
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PMID: 29724785
DOI: 10.1084/jem.20171487

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