Article
Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology.
International journal of molecular sciences - 4 Feb 2020
Schrank Sean, McDaid John, Briggs Clark A, Mustaly-Kalimi Sarah, Brinks Deanna, Houcek Aiden, Singer Oded, Bottero Virginie, Marr Robert A, Stutzmann Grace E
Abstract excerpt
Traditional approaches to studying Alzheimer's disease (AD) using mouse models and cell lines have advanced our understanding of AD pathogenesis. However, with the growing divide between model systems and clinical therapeutic outcomes, the limitations of these approaches are increasingly apparent. Thus, to generate more clinically relevant systems that capture pathological cascades within human neurons, we...
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