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Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease

2022-05-13

Abstract excerpt

Numerous evidence support that microglia contributes to the progression of Alzheimer’s disease. P2X4 receptors are ATP-gated channels, which are de novo expressed in a subset of reactive microglia associated to various pathological contexts, contributing to microglial functions. Here, we investigated the role of P2X4 in the context of Alzheimer disease (AD). In both human AD brain and APP swe /PSEN1 dE9 mice, P...

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Literature Corpus work
6a663fed-4886-5b1c-90d7-5b5e1bad678e
DOI
10.1101/2022.05.12.491601
Open publication

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Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer diseaseDOI 10.1101/2022.05.12.491601
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