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P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

15 Sept 2023

Abstract excerpt

The purinoceptor P2X7R is a promising therapeutic target for tauopathies, including Alzheimer’s disease (AD). Pharmacological inhibition or genetic knockdown of P2X7R ameliorates cognitive deficits and reduces pathological tau burden in mice that model aspects of tauopathy, including mice expressing mutant human frontotemporal dementia (FTD)-causing forms of tau. However, disagreements remain over which glial...

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PMID: 37716378
DOI: 10.1016/j.bbi.2023.09.011

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