Article

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer’s disease patients, and associated with amyloid and tau pathologies

2024-02-28

Abstract excerpt

<h4>INTRODUCTION</h4> The purinergic receptor P2X7R, which is expressed on microglia and astrocytes, plays an important role in Alzheimer’s disease (AD). We aimed to characterize the alterations in P2X7R expression in AD patients by APOE ε4 allele, age and sex, as well as its association with amyloid and tau pathology. <h4>METHODS</h4> P2X7R staining and quantitative analysis of amyloid, tau, astrocytes and micr...

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Literature Corpus work: 64617e8a-47fa-50d5-b5b1-330826e57a91
DOI: 10.1101/2024.02.28.582443

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