Article

Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer disease

2023-01-27

Abstract excerpt

<title>Abstract</title> <p>Numerous evidence support that microglia contributes to the progression of Alzheimer’s disease. P2X4 receptors are ATP-gated channels with high calcium permeability, which are de novo expressed in a subset of reactive microglia associated to various pathological contexts, contributing to microglial functions. P2X4 receptors trafficking to the plasma membrane is tightly regulated and are...

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Literature Corpus work: 4499f345-e25b-5291-a21b-27ada46934d4
DOI: 10.21203/rs.3.rs-2474390/v1

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