Article

Modulation of mitochondria-ER contacts decrease inflammasome formation and restores amyloid β-peptide phagocytosis in adult mouse microglia

2026-03-12

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, currently devoid of a cure. AD’s clinical manifestations stem from a multitude of dysfunctional cellular processes, regulated by mitochondria-endoplasmic contact sites (MERCS), which undergo physical alterations and malfunction in AD brain. Despite ongoing research, the understanding of MERCS in AD remains in its nascent...

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Literature Corpus work: 7c85d5a7-ff85-51b0-a978-611d1f7c7223
DOI: 10.64898/2026.03.10.710773

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