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Article

P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy

12 Aug 2021

Abstract excerpt

Alzheimer's disease is the most common form of dementia characterized by intracellular aggregates of hyperphosphorylated Tau protein and extracellular accumulation of amyloid β (Aβ) peptides. We previously demonstrated that the purinergic receptor P2X7 (P2X7) plays a major role in Aβ-mediated neurodegeneration but the relationship between P2X7 and Tau remained overlooked. Such a link was supported by cortical...

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PMID: 34391810
DOI: 10.1016/j.pneurobio.2021.102139

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