Article

Computational reconstruction of clonal hierarchies from bulk sequencing data of acute myeloid leukemia samples

2021-01-25

Abstract excerpt

Acute myeloid leukemia is an aggressive cancer of the blood forming system. The malignant cell population is composed of multiple clones that evolve over time. Clonal data reflect the mechanisms governing treatment response and relapse. Single cell sequencing provides most direct insights into the clonal composition of the leukemic cells, however it is still not routinely available in clinical practice. In this wo...

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Literature Corpus work: c0338993-dfa9-5c80-9c86-9894d4f665de
DOI: 10.1101/2021.01.23.427897

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