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A clinical solution for tracking clonal evolution of acute myeloid leukemia after allogeneic transplantation using bulk next generation sequencing.

Bone marrow transplantation - 1 Aug 2025

Krakow Elizabeth F, Lee Nathan, Jenkins Isaac, Sala-Torra Olga, Beppu Lan, Radich Jerald P, Fukuda Bryce, Sandmaier Brenda M, Yeung Cecilia Cs, Bozic Ivana

Abstract excerpt

Clinical next generation sequencing (NGS) typically relies on limited gene panels run on bulk marrow or blood. Current computational tools for inferring clonal relationships is generally limited by the use of a small panel of pathogenic mutations to define clones. We developed an online software (CloneTracker) that uses 'incidentally-sequenced' single nucleotide polymorphisms (SNPs) in the regions of recurrent...

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Share to Clonal Evolution
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

Share to Neoplasm, Residual

Share to Polymorphism, Single Nucleotide

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Share to Transplantation, Homologous

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Identifiers

PMID: 40379905
DOI: 10.1038/s41409-025-02602-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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