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Article

Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data.

BMC bioinformatics - 30 Aug 2021

Baghaarabani Leila, Goliaei Sama, Foroughmand-Araabi Mohammad-Hadi, Shariatpanahi Seyed Peyman, Goliaei Bahram

Abstract excerpt

BACKGROUND: Genetic heterogeneity of a cancer tumor that develops during clonal evolution is one of the reasons for cancer treatment failure, by increasing the chance of drug resistance. Clones are cell populations with different genotypes, resulting from differences in somatic mutations that occur and accumulate during cancer development. An appropriate approach for identifying clones is determining the variant...

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Identifiers

PMID: 34461827
DOI: 10.1186/s12859-021-04338-7
PMCID: PMC8404257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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