Article

Impact of clonal architecture on clinical course and prognosis in patients with myeloproliferative neoplasms

2022-09-26

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are caused by a somatic gain-of-function mutation in one of three “disease driver” genes JAK2, MPL or CALR . About half of MPN patients also carry additional somatic mutations that modify the clinical course. The order of acquisition of these gene mutations has been proposed to influence the phenotype and evolution of the disease. We studied 50 JAK2 -V617F-positive MPN patien...

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Identifiers and source

Literature Corpus work: 0379367a-7832-5eff-9035-5f5afbe67423
DOI: 10.1101/2022.09.24.509318

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