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Conifer: Clonal Tree Inference for Tumor Heterogeneity With Single-cell and Bulk Sequencing Data

2021-03-01

Abstract excerpt

<h4>Background: </h4> An important and effective step in cancer treatment is understanding the clonal evolution of cancer tumors. Clones are cell populations with different genotypes, resulting from the differences in the somatic mutations that occur and accumulate during cancer development. An appropriate approach for better understanding a tumor population is determining the variant allele frequency with which t...

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Literature Corpus work: 0161fa3c-a796-5fc8-a704-2a71da68cb0f
DOI: 10.21203/rs.3.rs-263502/v1

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