Article

Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid Leukemia

2025-06-01

Abstract excerpt

<h4>Background</h4> Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next generation sequencing technologies are being applied to AML for risk stratification and monitoring treatment response. We aimed to evaluate the efficiency of whole exome se...

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Literature Corpus work: 347f8481-1d30-54f1-8a6f-584059987cea
DOI: 10.1101/2025.05.30.656982

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