Article

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development

2025-12-22

Abstract excerpt

Congenital heart disease (CHD), the most common human birth defect, often results from disruptions in gene regulatory networks (GRNs) that control cardiac lineage specification and cell type identity during heart development. A conserved core set of cardiac transcription factors (TFs) orchestrates these processes through combinatorial interactions that are cell type-specific and tightly regulated across space and...

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Literature Corpus work: bfb439c4-62e9-5749-a4dd-55c711e8db9a
DOI: 10.64898/2025.12.19.695499

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