Article

Regulatory network hubs guide dynamic human lineage specification

2025-12-17

Abstract excerpt

Transcription factors (TFs), including DNA binding proteins and epigenetic co-regulators, control the timing of gene programs during lineage commitment 1 . However, systematically defining the dynamic activities of the human genome’s nearly 2000 TFs during development remains challenging 2,3 . Here, we use Perturb-Seq to map the transcriptional impact of nearly all human TFs and a subset of enhancers during card...

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Literature Corpus work: 32ffcafd-a9fa-5d07-b037-2a01eecf5e38
DOI: 10.64898/2025.12.15.694070

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