Article

Genome-Wide Fetalization of Enhancer Architecture in Heart Disease

2019-04-01

Abstract excerpt

Heart disease is associated with re-expression of key transcription factors normally active only during prenatal development of the heart. However, the impact of this reactivation on the genome-wide regulatory landscape in heart disease has remained obscure. Here we show that pervasive epigenomic changes occur in heart disease, with thousands of regulatory sequences reacquiring fetal-like chromatin signatures. We...

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Literature Corpus work: 00fa9287-f42c-5dcb-b690-b73f8ea894ff
DOI: 10.1101/591362

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