Article
Genome-wide compendium and functional assessment of in vivo heart enhancers.
Nature communications - 5 Oct 2016
Dickel Diane E, Barozzi Iros, Zhu Yiwen, Fukuda-Yuzawa Yoko, Osterwalder Marco, Mannion Brandon J, May Dalit, Spurrell Cailyn H, Plajzer-Frick Ingrid, Pickle Catherine S, Lee Elizabeth, Garvin Tyler H, Kato Momoe, Akiyama Jennifer A, Afzal Veena, Lee Ah Young, Gorkin David U, Ren Bing, Rubin Edward M, Visel Axel, Pennacchio Len A
Abstract excerpt
Whole-genome sequencing is identifying growing numbers of non-coding variants in human disease studies, but the lack of accurate functional annotations prevents their interpretation. We describe the genome-wide landscape of distant-acting enhancers active in the developing and adult human heart, an organ whose impairment is a predominant cause of mortality and morbidity. Using integrative analysis of >35...
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