Article

Decoding Chromatin Dynamics in Cardiac Organoids Reveals Genetic Drivers of Human Heart Development and Disease

2025-10-15

Abstract excerpt

Defining temporal gene regulatory programs driving human organogenesis is essential for understanding congenital defects. We combined a time-resolved, single-cell multi-omic atlas of human induced pluripotent stem cell-derived cardiac organoids with deep learning models of chromatin accessibility, enabling systematic discovery of cis-regulatory syntax underlying heart development and disease. This framework identi...

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Literature Corpus work: a7c4321d-d131-5458-ae04-3acd708fc833
DOI: 10.1101/2025.10.15.680997

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