Article

Mammalian epigenomic conservation of promoters and enhancers in the heart associates with trait-associated variation and impacts cardiomyocyte phenotypes

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Interindividual genetic variation associated with cardiovascular traits and disease is commonly found in the non-coding genome, suggesting regulatory changes underlie many genetic association signals. Mammalian gene regulation is controlled by promoters and enhancers with rapidly divergent activities. However, the interplay between human non- coding genetic variation and regulatory evolution rem...

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Literature Corpus work: ad652a70-0951-5fdd-a967-4db72cbbc8bd
DOI: 10.1101/2025.06.05.658128

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