Article

Single-nucleus multiomic landscape of congenital heart diseases reveals disease-specific genotypic profiles

2025-08-05

Abstract excerpt

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD), whereas hypoplastic left heart syndrome (HLHS) represents 2-3% of all CHDs. We analyzed the single-nucleus multiome profile of right ventricle samples obtained from children during routine cardiac surgery for correction of TOF or staged surgical palliation for HLHS to define cell types and characterize gene regulation states in di...

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Literature Corpus work: 3c1bd039-0dc2-5630-8073-3605a0f92f9b
DOI: 10.1101/2025.08.01.25332780

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