Article

Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failure

2025-05-09

Abstract excerpt

Heart failure is a leading cause of morbidity and mortality; yet gene regulatory mechanisms driving cell type-specific pathologic responses remain undefined. Here, we present the cell type-resolved transcriptomes, chromatin accessibility, histone modifications and chromatin organization of 36 non-failing and failing human hearts profiled from 776,479 cells spanning all cardiac chambers. Integrative analyses reveal...

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Literature Corpus work: 3ece3822-5208-57b9-b21b-8c7b4cc3755f
DOI: 10.1101/2025.05.08.25327176

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