Article
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease.
Cell - 22 Dec 2022
Ameen Mohamed, Sundaram Laksshman, Shen Mengcheng, Banerjee Abhimanyu, Kundu Soumya, Nair Surag, Shcherbina Anna, Gu Mingxia, Wilson Kitchener D, Varadarajan Avyay, Vadgama Nirmal, Balsubramani Akshay, Wu Joseph C, Engreitz Jesse M, Farh Kyle, Karakikes Ioannis, Wang Kevin C, Quertermous Thomas, Greenleaf William J, Kundaje Anshul
Abstract excerpt
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular development, we generated single-cell chromatin accessibility maps of human fetal heart tissues. We identified eight major differentiation trajectories involving primary cardiac cell types, each associated with dynamic transcription factor (TF) activity signatures. We contrasted regulatory landscapes of iPSC-derived cardiac...
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