Article

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

2022-06-29

Abstract excerpt

<h4>Summary</h4> Congenital heart defects, the most common birth disorders, are the clinical manifestation of anomalies in fetal heart development - a complex process involving dynamic spatiotemporal coordination among various precursor cell lineages. This complexity underlies the incomplete understanding of the genetic architecture of congenital heart diseases (CHDs). To define the multi-cellular epigenomic and...

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Literature Corpus work: bc9a79a8-9110-5e7b-8785-ca0ad32423d1
DOI: 10.1101/2022.06.29.498132

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