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Article

Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis.

Circulation research - 9 Oct 2020

VanOudenhove Jennifer, Yankee Tara N, Wilderman Andrea, Cotney Justin

Abstract excerpt

RATIONALE: There is growing evidence that common variants and rare sequence alterations in regulatory sequences can result in birth defects or predisposition to disease. Congenital heart defects are the most common birth defect and have a clear genetic component, yet only a third of cases can be attributed to structural variation in the genome or a mutation in a gene. The remaining unknown cases could be caused...

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Identifiers

PMID: 32772801
DOI: 10.1161/CIRCRESAHA.120.316704
PMCID: PMC7554226

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