Complementary human gene interaction maps from radiation hybrids and CRISPRi

Abstract excerpt

The only comprehensive human genetic interaction map was constructed using increased gene copy numbers in radiation hybrid (RH) cells. Recently, a second map restricted to essential genes was created using CRISPRi-induced loss-of-function alleles. Here, the two maps are compared to understand their similarities and differences. Both maps showed significant overlap with protein-protein interaction databases and ide...

Topics

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• Alleles
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Cas Systems
• Gene Regulatory Networks
• Genome, Human
• Genome-Wide Association Study
• Protein Interaction Maps
• Radiation Hybrid Mapping

Identifiers and source

Literature Corpus work

becd8064-b429-5b34-9529-0fbace15073b

DOI

10.1101/2024.02.05.579036