Article

Systematic discovery and classification of human cell line essential genes

2015-02-18

Abstract excerpt

The study of gene essentiality in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. Technological advances in genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 systems have set the stage for identifying human cell line core and context-dependent essential genes. However, first genera...

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Literature Corpus work: 9c17c7fc-9cab-5636-9b49-4e84a69b5327
DOI: 10.1101/015412

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