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Article

Complementary human gene interaction maps from radiation hybrids and CRISPRi.

Physiological genomics - 1 Jan 2026

Smith Desmond J

Abstract excerpt

The only comprehensive human genetic interaction map was constructed using increased gene copy numbers in radiation hybrid (RH) cells. Recently, a second map restricted to essential genes was created using CRISPR interference (CRISPRi)-induced loss-of-function alleles. Here, the two maps are compared to understand their similarities and differences. Both maps showed significant overlap with protein-protein...

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Identifiers

PMID: 41369550
DOI: 10.1152/physiolgenomics.00075.2025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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