Article

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Genetic variation at the Leucine-rich repeat kinase 2 (LRRK2) locus contributes to enhanced lifetime risk of familial and sporadic Parkinson’s disease. Previous data have demonstrated that recruitment to various membranes of the endolysosomal system results in LRRK2 activation. However, the mechanism(s) underlying LRRK2 activation at endolysosomal membranes and the cellular consequences of thes...

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Literature Corpus work: be41d1ba-dbbf-5137-869e-77365b46f4b9
DOI: 10.1101/2020.12.01.406223

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